A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of 99mTc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of preosteoclasts to functional osteoclasts induced by receptor activator of NF-B ligand (RANKL), through a prevalent NO-dependent mechanism.
Synthesis of NO-Donor Bisphosphonates and Their in Vitro Action on Bone Resorption
LAZZARATO, Loretta;ROLANDO, Barbara;LOLLI, Marco Lucio;FRUTTERO, Roberta;GASCO, Alberto;
2005-01-01
Abstract
A new class of bisphosphonates containing nitrooxy NO-donor functions has been developed. The products proved to display affinity for hydroxyapatite. Injection of 99mTc-labeled derivatives 11 and 18 into male rats showed a preferential accumulation of the compounds in bone as compared to blood and muscles. The products were found to inhibit the differentiation of preosteoclasts to functional osteoclasts induced by receptor activator of NF-B ligand (RANKL), through a prevalent NO-dependent mechanism.
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