Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquinesensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the –SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.

Synthesis and antimalarial activities of some furoxan sulfones and related furazans

GALLI, Ubaldina;LAZZARATO, Loretta;BERTINARIA, Massimo;SORBA, Giovanni;GASCO, Alberto;
2005

Abstract

Furoxan derivatives bearing a sulfone moiety at position 3 or 4 were synthesized and tested for their antimalarial action on the chloroquinesensitive D10 and the chloroquine-resistent W2 strains of Plasmodium falciparum. The furazan analogues were considered for comparison. The most active compounds were the products in which the –SO2R groups are at the 3-position of the furoxan system. These latter substances displayed an antimalarial activity in the μM range, possibly related in part to their ability to release NO.
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http://www.elsevier.com/wps/find/journaldescription.cws_home/505813/description#description
Plasmodium falciparum; Nitric oxide; Antimalarial; Furoxanyl sulfones
U. GALLI; L. LAZZARATO; M. BERTINARIA; G. SORBA; A. GASCO; S. PARAPINI; D. TARAMELLI
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/22963
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