A general procedure is reported for the selective preparation of S-methyl N-alkylthiocarbamates by methylthiocarbonylation of primary aliphatic amines, employing S,S-dimethyl dithiocarbonate (DMDTC) as a phosgene substitute. The reactions are carried out in water at r.t. and the target products are obtained in high yields (>95%) and with high purity (>99.5%). Also to be noted the complete chemoselectivity of the reactions.

A General, Facile, and Safe Procedure for the Preparation of S-Methyl N-Alkylthiocarbamates by Methylthiocarbonylation of Primary Aliphatic Amines with S,S-Dimethyl Dithiocarbonate

ARTUSO, EMMA;DEGANI, Jacopo;FOCHI, Rita;MAGISTRIS, CLAUDIO
2007

Abstract

A general procedure is reported for the selective preparation of S-methyl N-alkylthiocarbamates by methylthiocarbonylation of primary aliphatic amines, employing S,S-dimethyl dithiocarbonate (DMDTC) as a phosgene substitute. The reactions are carried out in water at r.t. and the target products are obtained in high yields (>95%) and with high purity (>99.5%). Also to be noted the complete chemoselectivity of the reactions.
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1096
1102
thiocarbamates; thiocarbonylation; dithiocarbonates; amines; chemoselectivity
ARTUSO E; CARVOLI G; DEGANI I; FOCHI R; MAGISTRIS C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/27534
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