General procedures are reported to prepare N-alkylureas, N,N'-dialkylureas, and N,N,N'-trialkylureas by carbonylation of aliphatic amines, employing S,S-dimethyl dithiocarbonate (DMDTC) as a phosgene substitute. All the reactions were carried out in water and all the target ureas were obtained in high yields (28 ex., average yield 94%) and with very high purity (>99.2%). Also to be noted is the complete exploitation of the reagent DMDTC.
Preparation of Mono-, Di-, and Trisubstituted Ureas by Carbonylation of Aliphatic Amines with S,S-Dimethyl Dithiocarbonate
ARTUSO, EMMA;DEGANI, Jacopo;FOCHI, Rita;MAGISTRIS, CLAUDIO
2007-01-01
Abstract
General procedures are reported to prepare N-alkylureas, N,N'-dialkylureas, and N,N,N'-trialkylureas by carbonylation of aliphatic amines, employing S,S-dimethyl dithiocarbonate (DMDTC) as a phosgene substitute. All the reactions were carried out in water and all the target ureas were obtained in high yields (28 ex., average yield 94%) and with very high purity (>99.2%). Also to be noted is the complete exploitation of the reagent DMDTC.
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