This study aimed at identifying factors related to sentinel lymph node (SLN) involvement in patients with tubular, cribriform, mucinous or papillary breast carcinoma and those related to non-SLN metastases if an SLN was positive. Multivariate analyses involved logistic and stepwise regressions. The SLNs harboured metastases in 85 of 572 cases, 78 of whom underwent axillary dissection; 19 presented non-SLN positive disease. Lack of lymphovascular invasion, a tumour size < or = 10 mm and a single SLN removed were the factors predicting an SLN metastasis rate <10%, and patients with these features could be candidates for no surgical axillary staging. A positive SLN proportion of < or = 50% and no lymphovascular invasion were associated with a <10% rate of non-SLN invasion; patients with a positive SLN and these features could be candidates for the omission of completion axillary dissection. The opposite presentation of these factors would mandate SLN biopsy and axillary dissection, respectively.

Sentinel lymph node biopsy and non-sentinel node involvement in special type breast carcinomas with a good prognosis

SAPINO, Anna;
2007-01-01

Abstract

This study aimed at identifying factors related to sentinel lymph node (SLN) involvement in patients with tubular, cribriform, mucinous or papillary breast carcinoma and those related to non-SLN metastases if an SLN was positive. Multivariate analyses involved logistic and stepwise regressions. The SLNs harboured metastases in 85 of 572 cases, 78 of whom underwent axillary dissection; 19 presented non-SLN positive disease. Lack of lymphovascular invasion, a tumour size < or = 10 mm and a single SLN removed were the factors predicting an SLN metastasis rate <10%, and patients with these features could be candidates for no surgical axillary staging. A positive SLN proportion of < or = 50% and no lymphovascular invasion were associated with a <10% rate of non-SLN invasion; patients with a positive SLN and these features could be candidates for the omission of completion axillary dissection. The opposite presentation of these factors would mandate SLN biopsy and axillary dissection, respectively.
2007
43(9)
1407
1414
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T68-4NT93RK-3&_user=525216&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=525216&md5=9fb58bfb2afdfdfa56328c2a45b97d2d
Sentinel lymph node; Non-sentinel lymph node; Breast cancer; Tubular carcinoma; Mucinous carcinoma; Papillary carcinoma; Isolated tumour cells; Micrometastasis
CSERNI G; BIANCHI S; VEZZOSI V; ARISIO R; BORI R; PETERSE JL; SAPINO A; DRIJKONINGEN M; KULKA J; EUSEBI V; FOSCHINI MP; BELLOCQ JP; MARIN C; THORSTENSON S; AMENDOEIRA I; REINER-CONCIN A; DECKER T
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/28433
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