Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.

Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes.

MALAVASI, Fabio;FUNARO, Ada;E. Ferrero;MATERA, Lina;CAMUSSI, Giovanni;
1986

Abstract

Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.
83
2443
2447
http://www.pnas.org/content/83/8/2443.long
F. Malavasi; C. Tetta; A. Funaro; G. Bellone; E. Ferrero; A. Colli Franzone; P. Dellabona; R. Rusci; L. Matera; G. Camussi; F. Caligaris-Cappio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/29457
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