Primary murine mixed lymphocyte culture was used to examine the Lyt phenotype of T-lymphocytes producing migration inhibitory factor (MIF) against alloantigens. Experiments with anti-Lyt 1 and anti-Lyt 2 monoclonal antibodies in the presence of rabbit complement showed that both the Lyt 1+ (helper) and Lyt 2+3+ (cytotoxic/suppressor) T cell subpopulations produced MIF after allogeneic stimulation.
Lyt phenotype of T-lymphocytes producing migration inhibitory factor (MIF) in primary murine mixed lymphocyte culture. / GIOVARELLI M ;MARTINOTTI MG ;CAVALLO GP ;LANDOLFO S. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - 60(1981), pp. 110-112.