The function of the mononuclear phagocyte system was assessed in vivo in 85 patients with primary and secondary glomerulonephritis, by measuring the clearance of IgG - sensitised 51Cr-labelled autologous erythrocytes. Eleven per cent of patients in clinical remission were found to have a delayed clearance, whereas impaired macrophage function was present in 62.5 per cent of the patients with major urinary abnormalities. Blockade of mononuclear phagocyte system, induced at least in part by unidentified factors, might have a role in development and perpetuation of glomerular injury.

Macrophage function in primary and secondary glomerulonephritis.

ROCCATELLO, Dario;AMOROSO, Antonio;
1985-01-01

Abstract

The function of the mononuclear phagocyte system was assessed in vivo in 85 patients with primary and secondary glomerulonephritis, by measuring the clearance of IgG - sensitised 51Cr-labelled autologous erythrocytes. Eleven per cent of patients in clinical remission were found to have a delayed clearance, whereas impaired macrophage function was present in 62.5 per cent of the patients with major urinary abnormalities. Blockade of mononuclear phagocyte system, induced at least in part by unidentified factors, might have a role in development and perpetuation of glomerular injury.
1985
21
661
665
Roccatello, Dario; Coppo, R.; Martina, G.; Rollino, C.; Basolo, B.; Picciotto, G.; Bayle, F.; Bajardi, P.; Amoroso, Antonio; Cordonnier, D.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/30918
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