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EnglishHemopexin (Hpx) is a plasma glycoprotein which is expressed only in the liver. It is synthesized at a lower rate in the fetal liver than in the adult, and its level increases during acute infections. As shown here, a fragment of the human hemopexin promoter spanning from positions -130 to +22 relative to the cap site is sufficient to direct cell-specific transcription of a reporter gene. Within this segment a short sequence, located between positions -120 and -104, is responsible for this effect. This positive cis-acting element, the Hpx A site, interacts with a family of nuclear proteins, some of which are present only in hepatoma cells. The potential meaning of these complex DNA-protein interactions and the homology with elements present on the promoter of other liver-specific and acute phase genes are discussed.
| Titolo: | The analysis of the human hemopexin promoter defines a new class of liver-specific genes. |
| Autori Riconosciuti: | |
| Autori: | POLI V ;SILENGO L ;ALTRUDA F ;CORTESE R |
| Data di pubblicazione: | 1989 |
| Abstract: | Hemopexin (Hpx) is a plasma glycoprotein which is expressed only in the liver. It is synthesized at a lower rate in the fetal liver than in the adult, and its level increases during acute infections. As shown here, a fragment of the human hemopexin promoter spanning from positions -130 to +22 relative to the cap site is sufficient to direct cell-specific transcription of a reporter gene. Within this segment a short sequence, located between positions -120 and -104, is responsible for this effect. This positive cis-acting element, the Hpx A site, interacts with a family of nuclear proteins, some of which are present only in hepatoma cells. The potential meaning of these complex DNA-protein interactions and the homology with elements present on the promoter of other liver-specific and acute phase genes are discussed. |
| Volume: | 17 |
| Pagina iniziale: | 9351 |
| Pagina finale: | 9365 |
| Parole Chiave: | hemopexin; liver; acute phase response |
| Rivista: | NUCLEIC ACIDS RESEARCH |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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