Imipenem is a beta-lactam carbapenem antibiotic, N-formimidoyl thienamycin-derivate. Imipenem is highly active against gram-negative aerobes and also highly active against gram-positive aerobes and virtually all anaerobes, with MICs very low and MBCs equal or only two-four dilution higher, it has a low degree of affinity for all types of beta-lactamases, shown a good post-antibiotic effect, it is a potent inhibitor to peptidoglycan with a greatest affinity for PBP2 and PBP1, in gram-negative bacteria, and for PBP3, PBP1 and PBP4, in gram-positive bacteria. The precocious bactericidal activity belongs to its low molecular weight, the characteristic of zwitterionic compound, to its hydrophobicity and to, in finally, its compact molecular structure.
[In vitro activity of imipenem (N-formimidoylthienamycin), a new carbapenem antibiotic]
CAVALLO, Rossana;
1986-01-01
Abstract
Imipenem is a beta-lactam carbapenem antibiotic, N-formimidoyl thienamycin-derivate. Imipenem is highly active against gram-negative aerobes and also highly active against gram-positive aerobes and virtually all anaerobes, with MICs very low and MBCs equal or only two-four dilution higher, it has a low degree of affinity for all types of beta-lactamases, shown a good post-antibiotic effect, it is a potent inhibitor to peptidoglycan with a greatest affinity for PBP2 and PBP1, in gram-negative bacteria, and for PBP3, PBP1 and PBP4, in gram-positive bacteria. The precocious bactericidal activity belongs to its low molecular weight, the characteristic of zwitterionic compound, to its hydrophobicity and to, in finally, its compact molecular structure.
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