The effect of Epomediol (Clesidren (R)) on the membrane ATPase and Adenylate Cyclase activities has been investigated using highly purified rat liver plasmamembranes. The drug, even at micromolar concentration, showed a significant stimulatory effect on Ca++/Mg++- ATPase, Ca++- ATPase and Adenylate Cyclase activities. In particular the effect on Ca++- ATPase activity suggests that the drug under study may favourably modulate the calcium intracellular homeostasis.
Effect of Epomediol on the ATPase and adenylate cyclase activities in plasmamembranes isolated from rat liver.
BARRERA, Giuseppina;PAROLA, Maurizio
1984-01-01
Abstract
The effect of Epomediol (Clesidren (R)) on the membrane ATPase and Adenylate Cyclase activities has been investigated using highly purified rat liver plasmamembranes. The drug, even at micromolar concentration, showed a significant stimulatory effect on Ca++/Mg++- ATPase, Ca++- ATPase and Adenylate Cyclase activities. In particular the effect on Ca++- ATPase activity suggests that the drug under study may favourably modulate the calcium intracellular homeostasis.
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