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EnglishMethylglyoxal (MeG) administration to rats doesn't cause any change in liver lysosome integrity; on the other hand, lysosome osmotic fragility appears highly increased at short times after the treatment. Concomitantly, a significant decrease of the residual latent activity of acid phosphatase (RLA = activity which cannot be unmasked by extensive hypo-osmotic shock) occurs. Cycloheximide (CHM), when administered shortly before MeG, prevents both the changes in RLA and in osmotic fragility. These results point to a big stimulation of autophagy in rat liver by MeG.
| Titolo: | Effect of methylglyoxal on rat liver lysosome-vacuolar apparatus. |
| Autori Riconosciuti: | |
| Autori: | ZURETTI MF ;BARRERA G ;CHIAVASSA P ;DIANZANI MU |
| Data di pubblicazione: | 1981 |
| Abstract: | Methylglyoxal (MeG) administration to rats doesn't cause any change in liver lysosome integrity; on the other hand, lysosome osmotic fragility appears highly increased at short times after the treatment. Concomitantly, a significant decrease of the residual latent activity of acid phosphatase (RLA = activity which cannot be unmasked by extensive hypo-osmotic shock) occurs. Cycloheximide (CHM), when administered shortly before MeG, prevents both the changes in RLA and in osmotic fragility. These results point to a big stimulation of autophagy in rat liver by MeG. |
| Volume: | 33 |
| Pagina iniziale: | 175 |
| Pagina finale: | 178 |
| Rivista: | RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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http://hdl.handle.net/2318/31407
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