Methylglyoxal (MeG) administration to rats doesn't cause any change in liver lysosome integrity; on the other hand, lysosome osmotic fragility appears highly increased at short times after the treatment. Concomitantly, a significant decrease of the residual latent activity of acid phosphatase (RLA = activity which cannot be unmasked by extensive hypo-osmotic shock) occurs. Cycloheximide (CHM), when administered shortly before MeG, prevents both the changes in RLA and in osmotic fragility. These results point to a big stimulation of autophagy in rat liver by MeG.
Effect of methylglyoxal on rat liver lysosome-vacuolar apparatus.
BARRERA, Giuseppina;DIANZANI, Mario Umberto
1981-01-01
Abstract
Methylglyoxal (MeG) administration to rats doesn't cause any change in liver lysosome integrity; on the other hand, lysosome osmotic fragility appears highly increased at short times after the treatment. Concomitantly, a significant decrease of the residual latent activity of acid phosphatase (RLA = activity which cannot be unmasked by extensive hypo-osmotic shock) occurs. Cycloheximide (CHM), when administered shortly before MeG, prevents both the changes in RLA and in osmotic fragility. These results point to a big stimulation of autophagy in rat liver by MeG.
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