Hepatocytes isolated from young and old rats were compared for glucagon binding and its biological effect. Liver cells from young rats showed a receptor binding of the hormone significantly higher than cells from old rats. Such a behaviour was paralleled by the activity of the hormone. In fact, the glucagon-dependent stimulation of adenylate cyclase in the hepatocytes from the former group of animals was twice as high as in the latter.

Age related changes of glucagon binding and activity in isolated rat hepatocytes. / POLI G ;CASSADER M ;CHIARPOTTO E ;BIASI F ;CECCHINI G ;PAGANO G. - In: INTERNATIONAL JOURNAL OF TISSUE REACTIONS. - ISSN 0250-0868. - 8(1986), pp. 367-371.

Age related changes of glucagon binding and activity in isolated rat hepatocytes.

POLI, Giuseppe;CASSADER, Maurizio;CHIARPOTTO, Elena Maria;BIASI, Fiorella;
1986

Abstract

Hepatocytes isolated from young and old rats were compared for glucagon binding and its biological effect. Liver cells from young rats showed a receptor binding of the hormone significantly higher than cells from old rats. Such a behaviour was paralleled by the activity of the hormone. In fact, the glucagon-dependent stimulation of adenylate cyclase in the hepatocytes from the former group of animals was twice as high as in the latter.
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POLI G ;CASSADER M ;CHIARPOTTO E ;BIASI F ;CECCHINI G ;PAGANO G
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/31738
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