We have studied antiproliferative effect of Aspergillus terreus extract on various cell lines: I-407 normal human cells, L-929 normal murine cells, K-562 erythroleukemic human cells, IAD lymphoblastoid human cells and B 95-8 monkey lymphoblastoid cells. K-562 and lymphoblastoid cells showed higher sensitivity to the extract. Moreover, 'a cytostatic dose' of the extract on K-562 cells (12.5 micrograms/ml showed a reduction of 3H-thymidine (but not of 14C-uracil) incorporation, leading us to hypothesize a prevalent action on DNA synthesis.

[Antiproliferative effect of an extract of Aspergillus terreus] / PUGLIESE A ;VIDOTTO V ;CERUTI M ;BIGLINO A. - In: GIORNALE DI BATTERIOLOGIA, VIROLOGIA ED IMMUNOLOGIA. - ISSN 0390-5462. - 79(1986), pp. 272-278.

[Antiproliferative effect of an extract of Aspergillus terreus]

PUGLIESE, Agostino;CERUTI, Maurizio;BIGLINO, Alberto
1986

Abstract

We have studied antiproliferative effect of Aspergillus terreus extract on various cell lines: I-407 normal human cells, L-929 normal murine cells, K-562 erythroleukemic human cells, IAD lymphoblastoid human cells and B 95-8 monkey lymphoblastoid cells. K-562 and lymphoblastoid cells showed higher sensitivity to the extract. Moreover, 'a cytostatic dose' of the extract on K-562 cells (12.5 micrograms/ml showed a reduction of 3H-thymidine (but not of 14C-uracil) incorporation, leading us to hypothesize a prevalent action on DNA synthesis.
79
272
278
PUGLIESE A ;VIDOTTO V ;CERUTI M ;BIGLINO A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/31796
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