A numerical reduction of total T cells has been evidenced in peripheral blood of patients with active multiple sclerosis. A contemporary raise in T helper/inducer cells was demonstrated in patients' cerebrospinal fluid. A significant reduction in T suppressor/cytotoxic cells could be detected only in patients' cerebrospinal fluid, while this subpopulation resulted to be less affected in patients' circulation. These data differed significantly from controls' values. We conclude that a redistribution of some T cell subpopulation between peripheral blood and central nervous system could account for the immunological derangements observed in active multiple sclerosis.

T lymphocyte redistribution between peripheral blood and cerebrospinal fluid in active multiple sclerosis. / BIGLINO A ;BAGGIO GF ;GIOANNINI P. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - 63(1984), pp. 150-153.

T lymphocyte redistribution between peripheral blood and cerebrospinal fluid in active multiple sclerosis.

BIGLINO, Alberto;GIOANNINI, Paolo
1984

Abstract

A numerical reduction of total T cells has been evidenced in peripheral blood of patients with active multiple sclerosis. A contemporary raise in T helper/inducer cells was demonstrated in patients' cerebrospinal fluid. A significant reduction in T suppressor/cytotoxic cells could be detected only in patients' cerebrospinal fluid, while this subpopulation resulted to be less affected in patients' circulation. These data differed significantly from controls' values. We conclude that a redistribution of some T cell subpopulation between peripheral blood and central nervous system could account for the immunological derangements observed in active multiple sclerosis.
63
150
153
BIGLINO A ;BAGGIO GF ;GIOANNINI P
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/31808
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