BACKGROUND: Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN AND RESULTS: We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence. CONCLUSIONS: Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.

Corticosteroids can reverse severe imatinib-induced hepatotoxicity

FERRERO, Dario;FAVA, Carmen;BOCCADORO, Mario
2006-01-01

Abstract

BACKGROUND: Imatinib can induce severe hepatotoxicity, in 1-5% of CML patients, many of whom need permanent imatinib discontinuation. DESIGN AND RESULTS: We report 5 CML patients who developed grade 3-4 hepatotoxicity after 2-8 months in imatinib. Different aetiologies of liver damage were ruled out and toxicity recurred in 2 patients with further attempts at low dose imatinib. In all patients prednisone or methylprednisolone at 25- 40 mg/day resolved hepatotoxicity in 3-8 weeks and allowed imatinib to be resumed at full doses. Corticosteroid were tapered off in 3-5 months without hepatotoxicity recurrence. CONCLUSIONS: Corticosteroid may avoid discontinuation for hepatotoxicity of the most effective anti-CML therapy.
2006
91(6) ECR27
78
80
http://www.haematologica.org/cgi/reprint/91/6_Suppl/ECR27
FERRERO D; POGLIANI EM; REGE-CAMBRIN G; FAVA C; MATTIOLI G; DELLACASA C; CAMPA E; PERFETTI P; FUMAGALLI M; BOCCADORO M
File in questo prodotto:
File Dimensione Formato  
corticosteroid reverse imatinib hepatotoxicity.pdf

Accesso aperto

Tipo di file: PDF EDITORIALE
Dimensione 81.49 kB
Formato Adobe PDF
81.49 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/32002
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 57
  • ???jsp.display-item.citation.isi??? ND
social impact