The effect of the inhibition of the endothelial release of nitric oxide (NO) on the hyperaemia which follows a 10 s coronary occlusion was studied in 5 anaesthetized dogs, keeping aortic blood pressure constant. The left circumflex coronary artery was occluded before and after the intracoronary infusion of an inhibitor of NO (LNNA). After LNNA, the peak amplitude of the hyperaemia was the same but the duration was reduced almost to a half of the control value; it is suggested that a myogenic vasodilatation is involved in the amplitude of the reactive hyperaemia, while the reduction in the duration of the hyperaemia after the inhibitor could result from the shear stress being less effective in causing the release of NO during the first part of the hyperaemia.
Endothelium and coronary reactive hyperaemia.
PAGLIARO, Pasquale
1993-01-01
Abstract
The effect of the inhibition of the endothelial release of nitric oxide (NO) on the hyperaemia which follows a 10 s coronary occlusion was studied in 5 anaesthetized dogs, keeping aortic blood pressure constant. The left circumflex coronary artery was occluded before and after the intracoronary infusion of an inhibitor of NO (LNNA). After LNNA, the peak amplitude of the hyperaemia was the same but the duration was reduced almost to a half of the control value; it is suggested that a myogenic vasodilatation is involved in the amplitude of the reactive hyperaemia, while the reduction in the duration of the hyperaemia after the inhibitor could result from the shear stress being less effective in causing the release of NO during the first part of the hyperaemia.
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