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EnglishThe effects of several monoclonal antibodies (MAbs) directed against different epitopes of HLA class I and class II antigens on interferon (IFN)-gamma and IFN-alpha production were studied. The results indicate that: these MAbs have a marked inhibitory effect on the production of IFN-gamma induced by alloantigens and microbial antigens; they influence only to a lesser extent staphylococcal enterotoxin B (SEB)- and phytohemagglutinin (PHA)-induced IFN-gamma production; such effects parallel inhibition of lymphoproliferation except for PHA-induced blastogenesis, which is not affected; on the other hand, these MAbs have no effect on the production of IFN-alpha induced by lipopolysaccharide (LPS) or viruses.
| Titolo: | Influence of monoclonal antibodies against HLA class I and class II antigen on interferon-gamma and -alpha induction. |
| Autori Riconosciuti: | |
| Autori: | AUSIELLO C ;SPAGNOLI GC ;ANTONELLI G ;MALAVASI F ;CASCIANI CU ;DIANZANI F |
| Data di pubblicazione: | 1987 |
| Abstract: | The effects of several monoclonal antibodies (MAbs) directed against different epitopes of HLA class I and class II antigens on interferon (IFN)-gamma and IFN-alpha production were studied. The results indicate that: these MAbs have a marked inhibitory effect on the production of IFN-gamma induced by alloantigens and microbial antigens; they influence only to a lesser extent staphylococcal enterotoxin B (SEB)- and phytohemagglutinin (PHA)-induced IFN-gamma production; such effects parallel inhibition of lymphoproliferation except for PHA-induced blastogenesis, which is not affected; on the other hand, these MAbs have no effect on the production of IFN-alpha induced by lipopolysaccharide (LPS) or viruses. |
| Volume: | 7 |
| Pagina iniziale: | 133 |
| Pagina finale: | 143 |
| Rivista: | JOURNAL OF INTERFERON RESEARCH |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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