The effects of several monoclonal antibodies (MAbs) directed against different epitopes of HLA class I and class II antigens on interferon (IFN)-gamma and IFN-alpha production were studied. The results indicate that: these MAbs have a marked inhibitory effect on the production of IFN-gamma induced by alloantigens and microbial antigens; they influence only to a lesser extent staphylococcal enterotoxin B (SEB)- and phytohemagglutinin (PHA)-induced IFN-gamma production; such effects parallel inhibition of lymphoproliferation except for PHA-induced blastogenesis, which is not affected; on the other hand, these MAbs have no effect on the production of IFN-alpha induced by lipopolysaccharide (LPS) or viruses.
Influence of monoclonal antibodies against HLA class I and class II antigen on interferon-gamma and -alpha induction. / AUSIELLO C ;SPAGNOLI GC ;ANTONELLI G ;MALAVASI F ;CASCIANI CU ;DIANZANI F. - In: JOURNAL OF INTERFERON RESEARCH. - ISSN 0197-8357. - 7(1987), pp. 133-143.
Titolo: | Influence of monoclonal antibodies against HLA class I and class II antigen on interferon-gamma and -alpha induction. |
Autori Riconosciuti: | |
Autori: | AUSIELLO C ;SPAGNOLI GC ;ANTONELLI G ;MALAVASI F ;CASCIANI CU ;DIANZANI F |
Data di pubblicazione: | 1987 |
Abstract: | The effects of several monoclonal antibodies (MAbs) directed against different epitopes of HLA class I and class II antigens on interferon (IFN)-gamma and IFN-alpha production were studied. The results indicate that: these MAbs have a marked inhibitory effect on the production of IFN-gamma induced by alloantigens and microbial antigens; they influence only to a lesser extent staphylococcal enterotoxin B (SEB)- and phytohemagglutinin (PHA)-induced IFN-gamma production; such effects parallel inhibition of lymphoproliferation except for PHA-induced blastogenesis, which is not affected; on the other hand, these MAbs have no effect on the production of IFN-alpha induced by lipopolysaccharide (LPS) or viruses. |
Volume: | 7 |
Pagina iniziale: | 133 |
Pagina finale: | 143 |
Rivista: | JOURNAL OF INTERFERON RESEARCH |
Appare nelle tipologie: | 03A-Articolo su Rivista |