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EnglishFollowing an intraperitoneal injection of ethanol (1 g/kg), spontaneous saccades performed by pigmented rats showed a backward post-saccadic drift which was still present 45 min after the administration. When 5 mg/kg of Ro 15-4513 were injected, 15 min after ethanol, there was an immediate remarkable reduction in post-saccadic drift amplitude, with a full recovery in about 30 min after Ro 15-4513 administration. This drug is thus able to reverse the effect of ethanol and to restore effectively a mechanism of motor integration.
| Titolo: | Antagonist action of imidazobenzodiazepine Ro 15-4513 on ethanol-induced alterations of saccadic eye movements in the pigmented rat. | |
| Autori Riconosciuti: | ||
| Autori: | Rossi, Ferdinando; Chelazzi, L.; Tempia, Filippo; Strata, Pier Giorgio | |
| Data di pubblicazione: | 1988 | |
| Abstract: | Following an intraperitoneal injection of ethanol (1 g/kg), spontaneous saccades performed by pigmented rats showed a backward post-saccadic drift which was still present 45 min after the administration. When 5 mg/kg of Ro 15-4513 were injected, 15 min after ethanol, there was an immediate remarkable reduction in post-saccadic drift amplitude, with a full recovery in about 30 min after Ro 15-4513 administration. This drug is thus able to reverse the effect of ethanol and to restore effectively a mechanism of motor integration. | |
| Volume: | 89 | |
| Pagina iniziale: | 69 | |
| Pagina finale: | 73 | |
| Rivista: | NEUROSCIENCE LETTERS | |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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