In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.

A single-nucleotide polymorphism in the human beta-defensin 1 gene is associated with HIV-1 infection in Italian children

TOVO, Pier Angelo;AMOROSO, Antonio;
2004

Abstract

In this study we show a significant correlation between a single-nucleotide polymorphism in the 5'-untranslated region of the DEFB1 gene, which probably regulates the gene expression of human beta defensin 1 (hBD-1) and the risk of HIV-1 infection in an Italian paediatric population (97 HIV-1 perinatally infected children), pointing to the importance of innate immunity in HIV-1 infection.
18(11)
1598
1600
http://www.aidsonline.com/pt/re/aids/pdfhandler.00002030-200407230-00016.pdf;jsessionid=JJFMxvQFcqsctX4BGFLZwnXpQLy1wSbVJZLh7w3jTV12Zy10vhMX!-975242908!181195629!8091!-1
HIV; beta Defensin; susceptibility
L. BRAIDA; M. BONIOTTO; A. PONTILLO; PA. TOVO; A. AMOROSO; S. CROVELLA
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/35271
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