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EnglishMetastasis to the liver is a frequent event in clinical oncology, the molecular mechanisms of which are not fully understood. We have recently reported a consistent overexpression of c-met in B16 melanoma cells selected in vivo for enhanced liver metastatic ability. In this study we address the question as to whether constitutive activation of c-met is a necessary and sufficient condition for enhanced liver colonization by B16 melanoma cells. Different levels of c-met expression and/or activation in B16 cells were achieved by subcloning, or by c-DNA transfection with either HGF/SF or the oncogenic form of c-met (tpr-met). Metastatic ability of the different populations was then evaluated in vivo by the lung colonization (experimental metastasis) assay. Results indicate that c-met (but not tpr-met) activation in B16 melanoma cells may increase their liver colonizing potential, probably by enhancing motility and invasion in response to paracrine interactions with its ligand. C-met expression per se, however, is not able to change the organ specificity of the cells. C-met activation appears instead to be required at later stages of liver colonization by B16 melanoma cells, in order to enhance their site-specific metastatic ability.
C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells. / LIN S; RUSCIANO D; LORENZONI P; HARTMANN G; BIRCHMEIER W; GIORDANO S; COMOGLIO P; BURGER MM. - In: CLINICAL & EXPERIMENTAL METASTASIS. - ISSN 0262-0898. - 16(1998), pp. 253-265.
| Titolo: | C-met activation is necessary but not sufficient for liver colonization by B16 murine melanoma cells. | |
| Autori Riconosciuti: | ||
| Autori: | LIN S; RUSCIANO D; LORENZONI P; HARTMANN G; BIRCHMEIER W; GIORDANO S; COMOGLIO P; BURGER MM | |
| Data di pubblicazione: | 1998 | |
| Abstract: | Metastasis to the liver is a frequent event in clinical oncology, the molecular mechanisms of which are not fully understood. We have recently reported a consistent overexpression of c-met in B16 melanoma cells selected in vivo for enhanced liver metastatic ability. In this study we address the question as to whether constitutive activation of c-met is a necessary and sufficient condition for enhanced liver colonization by B16 melanoma cells. Different levels of c-met expression and/or activation in B16 cells were achieved by subcloning, or by c-DNA transfection with either HGF/SF or the oncogenic form of c-met (tpr-met). Metastatic ability of the different populations was then evaluated in vivo by the lung colonization (experimental metastasis) assay. Results indicate that c-met (but not tpr-met) activation in B16 melanoma cells may increase their liver colonizing potential, probably by enhancing motility and invasion in response to paracrine interactions with its ligand. C-met expression per se, however, is not able to change the organ specificity of the cells. C-met activation appears instead to be required at later stages of liver colonization by B16 melanoma cells, in order to enhance their site-specific metastatic ability. | |
| Volume: | 16 | |
| Pagina iniziale: | 253 | |
| Pagina finale: | 265 | |
| Digital Object Identifier (DOI): | 10.1023/A:1006596909948 | |
| Rivista: | CLINICAL & EXPERIMENTAL METASTASIS | |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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