The indications for investigation on the LSD-25 'in vivo' activity on brain cholinesterases of the rat, have been considered. Indications of materials and method used have been supplied too. From the results obtained it emerged no clear evidence of a statistically significant inhibition of cholinesterases due to LSD-25. The results have been discussed and it has been evidenced that the lack of action of the psychotomimetic substance on cholinesterases could be only apparent or that the discrepancy between the LSD-25 anticholinesterase 'in vivo' and 'in vitro' action should be ascribed to the too scarce tissue levels which can be reached with the does utilized. Apart from the hypothesis, tending to explain the results obtained, it has been considered that the LSD-25 behavioural action, is not probably carried out thanks to a cholinesterase activity.

Azione dell'LSD-25 sulle colinesterasi del cervello di ratto[Effect of LSD-25 on cholinesterases of the rat brain]

TORRE, Carlo
1979-01-01

Abstract

The indications for investigation on the LSD-25 'in vivo' activity on brain cholinesterases of the rat, have been considered. Indications of materials and method used have been supplied too. From the results obtained it emerged no clear evidence of a statistically significant inhibition of cholinesterases due to LSD-25. The results have been discussed and it has been evidenced that the lack of action of the psychotomimetic substance on cholinesterases could be only apparent or that the discrepancy between the LSD-25 anticholinesterase 'in vivo' and 'in vitro' action should be ascribed to the too scarce tissue levels which can be reached with the does utilized. Apart from the hypothesis, tending to explain the results obtained, it has been considered that the LSD-25 behavioural action, is not probably carried out thanks to a cholinesterase activity.
1979
55
1515
1519
TORRE E.; PAVESI M.; TORRE C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/35649
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