Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria.

Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation

ALDIERI, Elisabetta;BERGANDI, Loredana;RIGANTI, Chiara;COSTAMAGNA, Costanzo;BOSIA, Amalia;GHIGO, Dario Antonio
2003

Abstract

Artemisinin is a natural product used as an alternative drug in the treatment of severe and multidrug-resistant malaria. In the present work we show that artemisinin shares with other sesquiterpene lactones the ability to inhibit the activation of the nuclear factor NF-kB: by this mechanism, artemisinin, as well as parthenolide, inhibits nitric oxide synthesis in cytokine-stimulated human astrocytoma T67 cells. These results suggest that artemisinin, in addition to its antiparasitic properties, could also exert a therapeutic effect on neurological complications of malaria.
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ALDIERI E.; ATRAGENE D.; BERGANDI L.; RIGANTI C.; COSTAMAGNA C.; A. BOSIA; GHIGO D.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/38959
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