Prolonged treatment of rats with a cholesterol-rich diet induced hypercholesterolaemia and increased free cholesterol content of peritoneal macrophages. A 2-2 times increase in plasma membrane cholesterol was demonstrated in cholesterol-enriched macrophages. These cells showed a significant inhibition of phagocytosis. The inhibition was 37-0% and 81-7% for latex particles or lipid droplets, respectively.

The influence of enrichment with cholesterol on the phagocytic activity of rat macrophages

DIANZANI, Umberto;CANUTO, Rosa Angela;
1976-01-01

Abstract

Prolonged treatment of rats with a cholesterol-rich diet induced hypercholesterolaemia and increased free cholesterol content of peritoneal macrophages. A 2-2 times increase in plasma membrane cholesterol was demonstrated in cholesterol-enriched macrophages. These cells showed a significant inhibition of phagocytosis. The inhibition was 37-0% and 81-7% for latex particles or lipid droplets, respectively.
1976
118
193
199
Dianzani MU; Torrielli MV; Canuto RA; Garcea R; Feo F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/39047
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