AIMS: To reveal architectural structure and growth patterns of tubular carcinomas (TC) and tubulo-lobular carcinomas (TLC) of the breast. METHODS AND RESULTS: We studied a series of 20 pure TC and 22 TLC, evaluating the architectural features of the two entities by bi-dimensional microscopy and by 3-D modelling. We traced the spatial organization of three TCs and three TLCs on serial sections using AE1/AE3 cytokeratin as a marker of the epithelial structures and reconstructed 3-D models of each histological type. The analysis of TC on serial cytokeratin-stained sections showed that the form of the 'tubules' was related to the plane of sectioning and that often they were tear-drop shaped, with a final tail of single cells connecting them together. 3-D models corresponded to a necklace appearance and the tubules of TC appeared as blebs bridging through solid cords to other blebs. In TLC the structure was similar, but the connecting single-cell files were usually longer. Both TC and TLC showed similar E-cadherin positivity and an indolent clinical behaviour. CONCLUSIONS: TC and TLC share the same architectural and growth patterns and ultimately seem to represent variants of the same tumour type.

A new vision of tubular and tubulo-lobular carcinomas of the breast, as revealed by 3-D modelling

MARCHIO', Caterina;SAPINO, Anna;BUSSOLATI, Giovanni
2006-01-01

Abstract

AIMS: To reveal architectural structure and growth patterns of tubular carcinomas (TC) and tubulo-lobular carcinomas (TLC) of the breast. METHODS AND RESULTS: We studied a series of 20 pure TC and 22 TLC, evaluating the architectural features of the two entities by bi-dimensional microscopy and by 3-D modelling. We traced the spatial organization of three TCs and three TLCs on serial sections using AE1/AE3 cytokeratin as a marker of the epithelial structures and reconstructed 3-D models of each histological type. The analysis of TC on serial cytokeratin-stained sections showed that the form of the 'tubules' was related to the plane of sectioning and that often they were tear-drop shaped, with a final tail of single cells connecting them together. 3-D models corresponded to a necklace appearance and the tubules of TC appeared as blebs bridging through solid cords to other blebs. In TLC the structure was similar, but the connecting single-cell files were usually longer. Both TC and TLC showed similar E-cadherin positivity and an indolent clinical behaviour. CONCLUSIONS: TC and TLC share the same architectural and growth patterns and ultimately seem to represent variants of the same tumour type.
2006
48
556
562
10.1111/j.1365-2559.2006.02373.x
architecture; breast carcinoma; reconstruction
MARCHIÒ C; SAPINO A; ARISIO R; BUSSOLATI G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/39707
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