Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the 'Italian Register for HIV infection in children', we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non-immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children.

Pertussis immunization in HIV-1-infected infants: a model to assess the effects of repeated T cell-dependent antigen administrations on HIV-1 progression. Italian Register for HIV infection in children.

TOVO, Pier Angelo;
2000-01-01

Abstract

Several data evidence that HIV-1 replication may increase in temporal association with immunizations, raising concerns on potential negative effects of vaccinations on HIV-1 progression. Among patients prospectively followed by the 'Italian Register for HIV infection in children', we evaluated, using the Cox-Mantel method, conditional probabilities of progressing to CDC clinical categories 'B' or 'C', and immunological categories '2' or '3' in 88 children immunized against pertussis and 244 non-immunized. No selection criteria were followed in vaccinating children. No significant differences were observed between the two groups. The lack of a significant impact on clinical and immunological deterioration by the repeated administrations of a T cell-dependent vaccine endorses the current recommendations for routine immunizations in HIV-1-infected children.
2000
18(13)
1203
1209
Perinatal HIV-l infection; Pertussis immunization; Disease progression
P. TOVO; M. DE MARTINO; C. GABIANO; L. GALLI
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/40525
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact