How do cytokines released by engineered tumour cells provoke tumour rejection and an immune memory? Is vaccination with tumour cells that have been engineered to secrete cytokines a viable therapeutic perspective? Piero Musiani and colleagues have sought an answer to these questions by transfecting the same tumour with the genes of various cytokines and elucidating the features of the reactions elicited.
Cytokines, tumour-cell death and immunogenicity: a question of choice.
GIOVARELLI, Mirella;CAVALLO, Federica;FORNI, Guido;
1997-01-01
Abstract
How do cytokines released by engineered tumour cells provoke tumour rejection and an immune memory? Is vaccination with tumour cells that have been engineered to secrete cytokines a viable therapeutic perspective? Piero Musiani and colleagues have sought an answer to these questions by transfecting the same tumour with the genes of various cytokines and elucidating the features of the reactions elicited.
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