The immunophenotype of peripheral blood lymphocytes was investigated in 23 dogs diagnosed with idiopathic pericardial effusion in order to provide information about a possible role of the immune system in this pathology. Flow cytometric analysis showed a significant reduction in nearly all lymphocyte subsets examined and a strong, significant (P<0.001) reduction of the CD4 subset, which gave rise to a significantly lower CD4/CD8 ratio. Our data suggest that an imbalance in the immune system is present during the course of the disease, preferentially affecting the T helper cell response.
Blood lymphocyte subsets in canine idiopathic pericardial effusion
MINISCALCO, Barbara;TARDUCCI, Alberto;BORGARELLI, Michele;RIONDATO, Fulvio;BORRELLI, Antonio;
2004-01-01
Abstract
The immunophenotype of peripheral blood lymphocytes was investigated in 23 dogs diagnosed with idiopathic pericardial effusion in order to provide information about a possible role of the immune system in this pathology. Flow cytometric analysis showed a significant reduction in nearly all lymphocyte subsets examined and a strong, significant (P<0.001) reduction of the CD4 subset, which gave rise to a significantly lower CD4/CD8 ratio. Our data suggest that an imbalance in the immune system is present during the course of the disease, preferentially affecting the T helper cell response.
File in questo prodotto:
| File | Dimensione | Formato | |
|---|---|---|---|
|
guglielmino 2004.pdf
Accesso riservato
Tipo di file:
PDF EDITORIALE
Dimensione
111.03 kB
Formato
Adobe PDF
|
111.03 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
