The immunophenotype of peripheral blood lymphocytes was investigated in 23 dogs diagnosed with idiopathic pericardial effusion in order to provide information about a possible role of the immune system in this pathology. Flow cytometric analysis showed a significant reduction in nearly all lymphocyte subsets examined and a strong, significant (P<0.001) reduction of the CD4 subset, which gave rise to a significantly lower CD4/CD8 ratio. Our data suggest that an imbalance in the immune system is present during the course of the disease, preferentially affecting the T helper cell response.

Blood lymphocyte subsets in canine idiopathic pericardial effusion

MINISCALCO, Barbara;TARDUCCI, Alberto;BORGARELLI, Michele;RIONDATO, Fulvio;BORRELLI, Antonio;
2004

Abstract

The immunophenotype of peripheral blood lymphocytes was investigated in 23 dogs diagnosed with idiopathic pericardial effusion in order to provide information about a possible role of the immune system in this pathology. Flow cytometric analysis showed a significant reduction in nearly all lymphocyte subsets examined and a strong, significant (P<0.001) reduction of the CD4 subset, which gave rise to a significantly lower CD4/CD8 ratio. Our data suggest that an imbalance in the immune system is present during the course of the disease, preferentially affecting the T helper cell response.
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GUGLIELMINO R; MINISCALCO B; TARDUCCI A; BORGARELLI M; RIONDATO F; ZINI E; BORRELLI A; BUSSADORI C
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/42015
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