Platelet activating factor (PAF) induces a biphasic effect on guinea-pig papillary muscle: 1. a transient positive inotropic effect preceded by an increase in action potential duration (APD); 2. a marked negative effect on inotropism and on APD. Since Ca++ slow action potentials were initially enhanced by PAF and then markedly depressed, it is suggested that PAF specifically interferes with the Ca++ slow channel.

Effect of platelet activating factor on guinea pig papillary muscle.

CAMUSSI, Giovanni;ALLOATTI, Giuseppe;MONTRUCCHIO, Giuseppe;
1984

Abstract

Platelet activating factor (PAF) induces a biphasic effect on guinea-pig papillary muscle: 1. a transient positive inotropic effect preceded by an increase in action potential duration (APD); 2. a marked negative effect on inotropism and on APD. Since Ca++ slow action potentials were initially enhanced by PAF and then markedly depressed, it is suggested that PAF specifically interferes with the Ca++ slow channel.
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CAMUSSI G; G. ALLOATTI; MONTRUCCHIO G; MEDA M; EMANUELLI G
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/42216
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