We evaluated the effect of the human immunodeficiency virus (HIV) protease inhibitor saquinavir on the imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cell lines. Saquinavir, which is also a proteasome blocker, showed dose- and time-related anti-proliferative activity, particularly on the imatinib-resistant lines and a pro-apoptotic effect. Association with imatinib caused a significant increase of activity.

The effects of saquinavir on imatinib-resistant chronic myelogenous leukemia cell lines

SAGLIO, Giuseppe;TOVO, Pier Angelo
2006-01-01

Abstract

We evaluated the effect of the human immunodeficiency virus (HIV) protease inhibitor saquinavir on the imatinib-sensitive and imatinib-resistant chronic myelogenous leukemia cell lines. Saquinavir, which is also a proteasome blocker, showed dose- and time-related anti-proliferative activity, particularly on the imatinib-resistant lines and a pro-apoptotic effect. Association with imatinib caused a significant increase of activity.
2006
91(5)
711
712
chronic myelogenous leukemm; saquinavir; protease inhibitors; proteasome inhibitors
TIMEUS F; CRESCENZIO N; RICOTTI E; DORIA A; BERTIN D; SAGLIO G; TOVO P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/42847
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