Two newGdEGTA( EGTA = ethylene glycol-bis(2-aminoethylether)N, N, N ', N '-tetraacetic acid) derivatives incorporating aromatic moieties into the oxoethylenic bridge have been prepared and characterised, their conjugates to HSA investigated and an unprecedented high relaxivity, close to that predicted by theory, interpreted in terms of the combined effect of restricted local rotation and fast rate of water exchange.

Maximizing the relaxivity of HSA-bound gadolinium complexes by simultaneous optimization of rotation and water exchange

AVEDANO, STEFANO;AIME, Silvio;LONGO, DARIO LIVIO;BOTTA, Mauro
2007-01-01

Abstract

Two newGdEGTA( EGTA = ethylene glycol-bis(2-aminoethylether)N, N, N ', N '-tetraacetic acid) derivatives incorporating aromatic moieties into the oxoethylenic bridge have been prepared and characterised, their conjugates to HSA investigated and an unprecedented high relaxivity, close to that predicted by theory, interpreted in terms of the combined effect of restricted local rotation and fast rate of water exchange.
2007
45
4726
4728
mri contrast agents; dynamics; nmr; gd; coordination; relaxation
Avedano S; Tei L; Lombardi A; Giovenzana GB; Aime S; Longo D; Botta M
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/44091
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