We describe the synthesis of a structure based on the iron carbonyl mediated head-to-head coupling of two molecules of 17 alpha-ethynylestradiol that leads ultimately to a ferrole. This compound was prepared with the aim of probing the mechanism of action of the estradiol receptor; spectroscopic, molecular modelling and biochemical studies are reported. The estradiol-ferrole cluster retains a weak, but not zero, affinity for the estradiol receptor. There is reversible binding to the receptor, and this is rationalized in terms of the pK(R+) value of - 13.1 found for the bioorganometallic complex.

Ferrole-estradiol complex as a test for receptor dimerization

OSELLA, Domenico;NERVI, Carlo;
1997

Abstract

We describe the synthesis of a structure based on the iron carbonyl mediated head-to-head coupling of two molecules of 17 alpha-ethynylestradiol that leads ultimately to a ferrole. This compound was prepared with the aim of probing the mechanism of action of the estradiol receptor; spectroscopic, molecular modelling and biochemical studies are reported. The estradiol-ferrole cluster retains a weak, but not zero, affinity for the estradiol receptor. There is reversible binding to the receptor, and this is rationalized in terms of the pK(R+) value of - 13.1 found for the bioorganometallic complex.
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97
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bioorganometallic chemistry; iron; molecular recognition; estradiol receptor; ORGANOMETALLIC DERIVATIVES; ESTROGEN-RECEPTOR; CO2(CO)6; BINDING
D. Osella; G. Dutto; C. Nervi; M. J. McGlinchey; A. Vessieres; G. Jaouen
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/44461
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