Reported here is a new procedure for the synthesis of alpha-arylpropionic acids in the racemic form, starting from derivatives of aromatic carboxylic acids (i.e. esters), via 1-aryl-2,2,2-tris(alkylsulfanyl)ethanones, S-alkyl (aryl)bis(alkylsulfanyl)thioacetates, S-alkyl alpha-aryl-alpha-(alkylsulfanyl)thiopropionates and S-alkyl alpha-arylthiopropionates. Each stage takes place easily and yields are always high.

An Interesting Synthetic Application of S-Alkyl (Aryl)bis(alkylsulfanyl)thioacetates: General Procedure for the Preparation of (+/-)-alpha-Arylpropionic Acids

CLERICUZIO, Marco;DEGANI, Jacopo;DUGHERA, Stefano;FOCHI, Rita
2002-01-01

Abstract

Reported here is a new procedure for the synthesis of alpha-arylpropionic acids in the racemic form, starting from derivatives of aromatic carboxylic acids (i.e. esters), via 1-aryl-2,2,2-tris(alkylsulfanyl)ethanones, S-alkyl (aryl)bis(alkylsulfanyl)thioacetates, S-alkyl alpha-aryl-alpha-(alkylsulfanyl)thiopropionates and S-alkyl alpha-arylthiopropionates. Each stage takes place easily and yields are always high.
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921
927
thioacetates; desulfurizations; thiols; arylpropionic acids; drugs
M. CLERICUZIO; I. DEGANI; S. DUGHERA; R. FOCHI
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/46458
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