Cerebral arteriovenous malformation (AVM) is a complex network of vascular channels consisting of arterial feeders, a nidus and enlarged venous drainage. AVMs usually increase in size with time, but may rarely obliterate; spontaneous angiographic regression occurs in less than 1.5% of cerebral AVMs. Several causes of spontaneous regression have been postulated such us hemodynamic alterations due to hemorrhage, hypercoagulability, atherosclerosis, and tromboembolism from associated aneurysms. In this report we describe a case of spontaneous, complete and asymptomatic occlusion of a left cerebellar hemispheric AVM; angiograms clearly demonstrate a progressive decrease in size of the AVM at follow-up. Thrombosis of the dominant-draining vein caused by turbulent blood flow seemed to be the main driver. Possible mechanisms leading to the occlusion are discussed and a review of the literature is reported. (c) 2008 Elsevier B.V. All rights reserved.

Progressive spontaneous occlusion of a cerebellar AVM: Pathogenetic hypothesis and review of literature

PANCIANI, PIER PAOLO;FONTANELLA, Marco Maria;CARLINO, christian francesco;BERGUI, Mauro;DUCATI, Alessandro
2008

Abstract

Cerebral arteriovenous malformation (AVM) is a complex network of vascular channels consisting of arterial feeders, a nidus and enlarged venous drainage. AVMs usually increase in size with time, but may rarely obliterate; spontaneous angiographic regression occurs in less than 1.5% of cerebral AVMs. Several causes of spontaneous regression have been postulated such us hemodynamic alterations due to hemorrhage, hypercoagulability, atherosclerosis, and tromboembolism from associated aneurysms. In this report we describe a case of spontaneous, complete and asymptomatic occlusion of a left cerebellar hemispheric AVM; angiograms clearly demonstrate a progressive decrease in size of the AVM at follow-up. Thrombosis of the dominant-draining vein caused by turbulent blood flow seemed to be the main driver. Possible mechanisms leading to the occlusion are discussed and a review of the literature is reported. (c) 2008 Elsevier B.V. All rights reserved.
CLINICAL NEUROLOGY AND NEUROSURGERY
110
502
510
P. P. Panciani; M. Fontanella; C. Carlino; M. Bergui; A. Ducati
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/50375
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