Level of neuron-specific enolase (NSE) in cerebrospinal fluid and serum of 16 goat in advanced stage of scrapie, 11 goats in the initial stage and 8 control animals have been evaluated. As alredy revealed in Creutzfeldt-Jacobs Disease (CID) in man, a statistically significant increase (P<0,05) of NSE levels in the initial stage of the disease has been observed. NSE may be considered useful biochemical marker of neuronal damage of the central nervous system (CSN), as well as a pre-clinical indication for the early diagnosis of transmissible spongiform encephalopathies.

VALUTAZIONI DEL LIVELLO DI ENOLASI NEURONE-SPECIFICA (NSE) NEL LIQUIDO CEFALORACHIDIANO (CSF) E NEL SIERO PER LA DIAGNOSI DI SCRAPIE NEI CAPRINI: DATI PRELIMINARI

AMEDEO, Stefano;CAPUCCHIO, Maria Teresa;BOLLO, Enrico;GUARDA, Franco
1999-01-01

Abstract

Level of neuron-specific enolase (NSE) in cerebrospinal fluid and serum of 16 goat in advanced stage of scrapie, 11 goats in the initial stage and 8 control animals have been evaluated. As alredy revealed in Creutzfeldt-Jacobs Disease (CID) in man, a statistically significant increase (P<0,05) of NSE levels in the initial stage of the disease has been observed. NSE may be considered useful biochemical marker of neuronal damage of the central nervous system (CSN), as well as a pre-clinical indication for the early diagnosis of transmissible spongiform encephalopathies.
1999
3
157
166
SCRAPIE; GOAT; NSE; CEREBROSPINAL FLUID; SERUM
MANZARDO E.; AMEDEO S.; DI MARCO V; CAPUCCHIO MT.; BOLLO E; CARACAPPA S.; GUARDA F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/53384
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