Two AML patients, whose leukemic clonogenic cells totally reacted to the anti-lactofucopentaose III S4-7 monoclonal antibody (MoAb), underwent autologous bone marrow transplantation, in first complete remission, after in-vitro purging with S4-7 MoAb and complement. After ablative chemotherapy (BAVC regimen) and reinfusion of S4-7 purged cells, regeneration of marrow cells occurred with prompt recovery of granulopoiesis and erythropoiesis. A more delayed platelet recovery was observed. The two patients are in complete remission at 20 and 11 months from ABMT. The results indicate that immunologic purging with S4-7 MoAb is safe and suitable for selected AML patients undergoing ABMT.

Autologous bone marrow transplantation in acute myeloid leukemia after in-vitro purging with an anti-lacto-N-fucopentaose III antibody and rabbit complement. / Ferrero D; De Fabritiis P; Amadori S; De Felice L; Gallo E; Meloni G; Pregno P; Pulsoni A; Simone F; Tarella C; Pileri A; Rovera G; Mandelli F. - In: LEUKEMIA RESEARCH. - ISSN 0145-2126. - 11(3)(1987), pp. 265-272.

Autologous bone marrow transplantation in acute myeloid leukemia after in-vitro purging with an anti-lacto-N-fucopentaose III antibody and rabbit complement.

FERRERO, Dario;GALLO, Eugenio;TARELLA, Corrado;PILERI, Alessandro;ROVERA, Giovanni Giac.;
1987

Abstract

Two AML patients, whose leukemic clonogenic cells totally reacted to the anti-lactofucopentaose III S4-7 monoclonal antibody (MoAb), underwent autologous bone marrow transplantation, in first complete remission, after in-vitro purging with S4-7 MoAb and complement. After ablative chemotherapy (BAVC regimen) and reinfusion of S4-7 purged cells, regeneration of marrow cells occurred with prompt recovery of granulopoiesis and erythropoiesis. A more delayed platelet recovery was observed. The two patients are in complete remission at 20 and 11 months from ABMT. The results indicate that immunologic purging with S4-7 MoAb is safe and suitable for selected AML patients undergoing ABMT.
11(3)
265
272
Ferrero D; De Fabritiis P; Amadori S; De Felice L; Gallo E; Meloni G; Pregno P; Pulsoni A; Simone F; Tarella C; Pileri A; Rovera G; Mandelli F
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/56363
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