The supramolecular adducts of negatively charged hyaluronic acid polymers and cationic Gd-liposomes were used for labeling cells that overexpress CD44 receptors. This cellular labeling methodology is very efficient and allows the internalization of a large payload of soluble Gd complexes in a very short timeframe.
Efficient Cellular Labeling by CD44 Receptor-Mediated Uptake of Cationic Liposomes Functionalized with Hyaluronic Acid and Loaded with MRI Contrast Agents
ESPOSITO, Giovanna;GENINATTI CRICH, Simonetta;AIME, Silvio
2008-01-01
Abstract
The supramolecular adducts of negatively charged hyaluronic acid polymers and cationic Gd-liposomes were used for labeling cells that overexpress CD44 receptors. This cellular labeling methodology is very efficient and allows the internalization of a large payload of soluble Gd complexes in a very short timeframe.
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