Experimental guinea pig asthma is a reliable and clinically relevant facsimile of human disease. The guinea pig is the preferred choice for use as a model of allergic bronchial asthma in the evaluation of anti-asthmatic drugs, since the airway anatomy and the response to inflammatory mediators is similar to humans. Further, the great strength of this model is the direct anaphylactic bronchoconstriction upon antigen challenge. Under certain conditions a late asthmatic response can be measured and airway hyperresponsiveness is observed in vitro and in vivo. Moreover, the inflammatory response is comparable with the human situation. More recent studies describe a chronic model for asthma in which airway remodeling is induced as can be observed in the asthmatic patients. The focus here is to demonstrate that guinea pig asthma models are useful for testing novel therapeutics

The guinea pig as an animal model for asthma

RICCIARDOLO, Fabio Luigi Massimo;DE ROSE, Virginia;
2008

Abstract

Experimental guinea pig asthma is a reliable and clinically relevant facsimile of human disease. The guinea pig is the preferred choice for use as a model of allergic bronchial asthma in the evaluation of anti-asthmatic drugs, since the airway anatomy and the response to inflammatory mediators is similar to humans. Further, the great strength of this model is the direct anaphylactic bronchoconstriction upon antigen challenge. Under certain conditions a late asthmatic response can be measured and airway hyperresponsiveness is observed in vitro and in vivo. Moreover, the inflammatory response is comparable with the human situation. More recent studies describe a chronic model for asthma in which airway remodeling is induced as can be observed in the asthmatic patients. The focus here is to demonstrate that guinea pig asthma models are useful for testing novel therapeutics
9
6
452
465
http://www.benthamdirect.org
Allergy; asthma; guinea pig; early asthmatic reaction; late asthmatic reaction; airway hyperresponsiveness; airway inflammation; airway remodelling
Ricciardolo FLM; Nijkamp F; De Rose V; Folkerts G
File in questo prodotto:
File Dimensione Formato  
Ricciardolo CurrDrug2008____.pdf

Accesso riservato

Tipo di file: POSTPRINT (VERSIONE FINALE DELL’AUTORE)
Dimensione 288.23 kB
Formato Adobe PDF
288.23 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/57602
Citazioni
  • ???jsp.display-item.citation.pmc??? 13
  • Scopus 53
  • ???jsp.display-item.citation.isi??? 50
social impact