The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.

Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies.

PANDOLFI DE RINALDIS, Pier Paolo
2007-01-01

Abstract

The promyelocytic leukaemia (PML) tumour suppressor protein epitomizes the PML-nuclear body (PML-NB) and is crucially required for the proper assembly of this macromolecular nuclear structure. Unlike other, more specialized subnuclear structures such as Cajal and Polycomb group bodies, PML-NBs are functionally promiscuous and have been implicated in the regulation of diverse cellular functions. PML-NBs are dynamic structures that favour the sequestration and release of proteins, mediate their post-translational modifications and promote specific nuclear events in response to various cellular stresses. Recent data suggest that PML-NBs may be heterogeneous in composition, mobility and function.
2007
8
1006
1016
http://dx.doi.org/10.1038/nrm2277
http://www.nature.com/nrm/journal/v8/n12/pdf/nrm2277.pdf
Animals; Cell Nucleus Structures; Humans; Intranuclear Inclusion Bodies; Neoplasm Proteins; Nuclear Proteins; Transcription Factors; Tumor Suppressor Proteins
R. Bernardi;P. P. Pandolfi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/61457
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