Single-channel properties of a cloned channel activated by cyclic GMP have been analysed. The ionic selectivity and the blockage by divalent cations of the native channel found in amphibian rods and in the cloned channel from bovine rods results to be quite similar. However, the cloned channel has well-resolved openings, especially at positive membrane voltages, wheras the native channel is characterized by a continuous flickering between the open and closed state.
Single-channel properties of cloned cGMP-activated channels from retinal rods
GIRAUDO, Maria Teresa;
1993-01-01
Abstract
Single-channel properties of a cloned channel activated by cyclic GMP have been analysed. The ionic selectivity and the blockage by divalent cations of the native channel found in amphibian rods and in the cloned channel from bovine rods results to be quite similar. However, the cloned channel has well-resolved openings, especially at positive membrane voltages, wheras the native channel is characterized by a continuous flickering between the open and closed state.
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