Through scientific and technological advancements, our ability to manipulate the mouse genome has allowed us to evaluate the effect of specific genetic alterations on in vivo tumorigenesis. This has allowed and will allow us to define molecular pathways describing the processes of tumor initiation, invasion, and progression to metastatic disease. Additionally, these models may serve as an excellent platform for the identification of novel molecular targets for therapy as well as to evaluate the efficacy of targeted therapies. Ultimately this will translate from preclinical mouse model trials to the development of clinical trials and protocols for cancer patients. Here we review the usefulness of mouse modeling in oncologic translational research.

Mouse modeling in oncologic preclinical and translational research.

PANDOLFI DE RINALDIS, Pier Paolo
2006-01-01

Abstract

Through scientific and technological advancements, our ability to manipulate the mouse genome has allowed us to evaluate the effect of specific genetic alterations on in vivo tumorigenesis. This has allowed and will allow us to define molecular pathways describing the processes of tumor initiation, invasion, and progression to metastatic disease. Additionally, these models may serve as an excellent platform for the identification of novel molecular targets for therapy as well as to evaluate the efficacy of targeted therapies. Ultimately this will translate from preclinical mouse model trials to the development of clinical trials and protocols for cancer patients. Here we review the usefulness of mouse modeling in oncologic translational research.
2006
Inglese
Sì, ma tipo non specificato
12
5305
5311
6
http://dx.doi.org/10.1158/1078-0432.CCR-06-0482
Animals; Disease Models; Animal; Drug Design; Drug Evaluation; Preclinical; Gene Deletion; Humans; Leukemia; Promyelocytic; Acute; Male; Mice; Transgenic; Models; Biological; Multipotent Stem Cells; Neoplasms; Oncogene Protein v-akt; PTEN Phosphohydrolase; Prostatic Neoplasms; Xenograft Model Antitumor Assays
262
2
B. S. Carver;P. P. Pandolfi
info:eu-repo/semantics/article
none
03-CONTRIBUTO IN RIVISTA::03A-Articolo su Rivista
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/62758
Citazioni
  • ???jsp.display-item.citation.pmc??? 21
  • Scopus 53
  • ???jsp.display-item.citation.isi??? 50
social impact