Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.

The transcription factor Pokemon: a new key player in cancer pathogenesis.

PANDOLFI DE RINALDIS, Pier Paolo
2005-01-01

Abstract

Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.
2005
65
8575
8578
http://dx.doi.org/10.1158/0008-5472.CAN-05-1055
Animals; Cell Transformation; Neopl; DNA-Binding Proteins; Humans; Mice; Transcription Factors; astic
T. Maeda;R. M. Hobbs;P. P. Pandolfi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/63762
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