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EnglishSummary. Angiogenesis is a dynamic, hypoxiastimulated and growth factor-dependent process, eventually leading to the formation of new vessels from pre-existing blood vessels. In the last decade experimental and clinical studies have described the occurrence of hepatic angiogenesis in a number of different pathophysiological conditions, including those involving inflammatory, fibrotic and ischemic features. In particular, the literature evidence indicates that hepatic angiogenesis is strictly associated with, and may even favour fibrogenic progression of chronic inflammatory liver diseases of different aetiology. In this review, current “in vivo” and “in vitro” evidence supporting the potential pathogenetic role of angiogenesis in chronic liver diseases will be reviewed in an attempt to outline cellular and molecular mechanisms involved, with a specific emphasis on the crucial role of hypoxic conditions and hepatic stellate cells (HSCs), particularly when activated to the myofibroblast-like pro-fibrogenic phenotype.
Angiogenesis and liver fibrogenesis / Valfrè di Bonzo L; Novo E; Cannito S; Busletta C; Paternostro C; Povero D; Parola M.. - In: HISTOLOGY AND HISTOPATHOLOGY. - ISSN 0213-3911. - STAMPA. - 24(2009), pp. 1323-1341.
| Titolo: | Angiogenesis and liver fibrogenesis |
| Autori Riconosciuti: | |
| Autori: | Valfrè di Bonzo L; Novo E; Cannito S; Busletta C; Paternostro C; Povero D; Parola M. |
| Data di pubblicazione: | 2009 |
| Abstract: | Summary. Angiogenesis is a dynamic, hypoxiastimulated and growth factor-dependent process, eventually leading to the formation of new vessels from pre-existing blood vessels. In the last decade experimental and clinical studies have described the occurrence of hepatic angiogenesis in a number of different pathophysiological conditions, including those involving inflammatory, fibrotic and ischemic features. In particular, the literature evidence indicates that hepatic angiogenesis is strictly associated with, and may even favour fibrogenic progression of chronic inflammatory liver diseases of different aetiology. In this review, current “in vivo” and “in vitro” evidence supporting the potential pathogenetic role of angiogenesis in chronic liver diseases will be reviewed in an attempt to outline cellular and molecular mechanisms involved, with a specific emphasis on the crucial role of hypoxic conditions and hepatic stellate cells (HSCs), particularly when activated to the myofibroblast-like pro-fibrogenic phenotype. |
| Volume: | 24 |
| Pagina iniziale: | 1323 |
| Pagina finale: | 1341 |
| Rivista: | HISTOLOGY AND HISTOPATHOLOGY |
| Appare nelle tipologie: | 03A-Articolo su Rivista |
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| Histol Histopathol 2009.pdf | PDF EDITORIALE | Accesso aperto | Open Access Visualizza/Apri |
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