Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology

Multiple ADH genes are associated with upper aerodigestive cancers

MERLETTI, Franco;RICHIARDI, Lorenzo;
2008-01-01

Abstract

Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology
2008
40
707
709
HASHIBE M; MCKAY JD; CURADO MP; OLIVEIRA JC; KOIFMAN S; KOIFMAN R; ZARIDZE D; SHANGINA O; WUNSCH-FILHO V; ELUF-NETO J; LEVI JE; MATOS E; LAGIOU P; LAGIOU A; BENHAMOU S; BOUCHARDY C; SZESZENIA-DABROWSKA N; MENEZES A; DALL'AGNOL MM; MERLETTI F; RICHIARDI L; FERNANDEZ L; LENCE J; TALAMINI R; BARZAN L; MATES D; MATES IN; KJAERHEIM K; MACFARLANE GJ; MACFARLANE TV; SIMONATO L; CANOVA C; HOLCATOVA I; AGUDO A; CASTELLSAGUE X; LOWRY R; JANOUT V; KOLLAROVA H; CONWAY DI; MCKINNEY PA; ZNAOR A; FABIANOVA E; BENCKO V; LISSOWSKA J; CHABRIER A; HUNG RJ; GABORIEAU V; BOFFETTA P; BRENNAN P
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/69454
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