The synthesis of a dimeric derivative of Gd-AAZTA is reported. It retains the basic properties of the parent complex (q = 2, high stability) and displays a relaxivity of 14.0 mM<sup>- 1</sup> s<sup>- 1</sup> at 20 MHz and 298 K. The outstanding relaxivity is the result of the increased molecular reorientational time and of the contribution arising from 4 to 5 water molecules in the second coordination sphere of the Gd(III) ions. © 2010 Elsevier B.V. All rights reserved.
Improving the relaxivity by dimerizing Gd-AAZTA: Insights for enhancing the sensitivity of MRI contrast agents
AIME, Silvio;GIANOLIO, Eliana
2010-01-01
Abstract
The synthesis of a dimeric derivative of Gd-AAZTA is reported. It retains the basic properties of the parent complex (q = 2, high stability) and displays a relaxivity of 14.0 mM- 1 s- 1 at 20 MHz and 298 K. The outstanding relaxivity is the result of the increased molecular reorientational time and of the contribution arising from 4 to 5 water molecules in the second coordination sphere of the Gd(III) ions. © 2010 Elsevier B.V. All rights reserved.File in questo prodotto:
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