Objective: To evaluate the frequency of neurobehavioral symptoms related to FTLD in a consecutive series of amyotrophic lateral sclerosis (ALS) patients and to assess their influence on patients and caregivers mood, burden, and quality of life. Methods: A total of 70 couples of ALS patients and their caregivers consecutively seen in our ALS clinic were separately interviewed using a battery of tests assessing frontotemporal-related neurobehavioral symptoms, emotional status, and quality of life. Patients behavioral abnormalities were assessed with the Frontal Systems Behavior Scale (FrSBe). Caregiver burden was assessed with the Caregiver Burden Inventory (CBI). Results: According to caregivers evaluations, 34 (48.6%) patients had FrSBe pathological scores at the time of the interview. According to patients evaluation, 9 (12.9%) patients had pathological scores at the time of the interview. In caregivers assessment, at the time of the interview the most commonly impaired neurobehavioral domain was apathy (39 patients, 55.7%), followed by executive dysfunction (32, 45.7%) and disinhibition (18, 25.7%). Neurobehavioral symptoms were related to the presence of bulbar symptoms at the time of the interview, but not to patients age, gender, or physical status (ALS-FRS score). Patients neurobehavioral symptoms were significantly related to lower caregivers quality of life, highest depression, and highest burden, both in univariate and in multivariable analyses. Conclusions: Neurobehavioral symptoms were present in 50% of our ALS patients and were related to bulbar symptoms. They have a profound negative impact on caregivers psychological status and were highly related with caregivers burden.

Neurobehavioral symptoms in ALS are negatively related to caregivers' burden and quality of life

CHIO', Adriano;MASTRO, Enza;CALVO, Andrea;MOGLIA, CRISTINA;MONTUSCHI, ANNA
2010

Abstract

Objective: To evaluate the frequency of neurobehavioral symptoms related to FTLD in a consecutive series of amyotrophic lateral sclerosis (ALS) patients and to assess their influence on patients and caregivers mood, burden, and quality of life. Methods: A total of 70 couples of ALS patients and their caregivers consecutively seen in our ALS clinic were separately interviewed using a battery of tests assessing frontotemporal-related neurobehavioral symptoms, emotional status, and quality of life. Patients behavioral abnormalities were assessed with the Frontal Systems Behavior Scale (FrSBe). Caregiver burden was assessed with the Caregiver Burden Inventory (CBI). Results: According to caregivers evaluations, 34 (48.6%) patients had FrSBe pathological scores at the time of the interview. According to patients evaluation, 9 (12.9%) patients had pathological scores at the time of the interview. In caregivers assessment, at the time of the interview the most commonly impaired neurobehavioral domain was apathy (39 patients, 55.7%), followed by executive dysfunction (32, 45.7%) and disinhibition (18, 25.7%). Neurobehavioral symptoms were related to the presence of bulbar symptoms at the time of the interview, but not to patients age, gender, or physical status (ALS-FRS score). Patients neurobehavioral symptoms were significantly related to lower caregivers quality of life, highest depression, and highest burden, both in univariate and in multivariable analyses. Conclusions: Neurobehavioral symptoms were present in 50% of our ALS patients and were related to bulbar symptoms. They have a profound negative impact on caregivers psychological status and were highly related with caregivers burden.
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Chiò A; Vignola A; Mastro E; Giudici AD; Iazzolino B; Calvo A; Moglia C; Montuschi A
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/74674
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