A series of nanoporous silica matrices (a silica gel matrix and two ordered mesoporous silica) have been investigated as potential carriers for the controlled release of metoprolol tartrate a selective b1 receptor blocker used in the treatment of several diseases of the cardiovascular system. Particular attention was devoted to the optimisation of a reproducible and fast synthetic procedure. The textural properties, structure and chemical nature of the porous surfaces were characterised by N2 physisorption, X-ray diffraction, HR-TEM and FTIR analyses. The delivery profiles were collected in vitro in physiological solution at pH 7.4. It has been possible to observe a close correlation between the drug release kinetic and the textural properties of the carriers.

Controlled release of metoprolol tartrate from nanoporous silica matrices

CROCELLA', VALENTINA;BERTINETTI, Luca;CERRATO, Giuseppina
2010-01-01

Abstract

A series of nanoporous silica matrices (a silica gel matrix and two ordered mesoporous silica) have been investigated as potential carriers for the controlled release of metoprolol tartrate a selective b1 receptor blocker used in the treatment of several diseases of the cardiovascular system. Particular attention was devoted to the optimisation of a reproducible and fast synthetic procedure. The textural properties, structure and chemical nature of the porous surfaces were characterised by N2 physisorption, X-ray diffraction, HR-TEM and FTIR analyses. The delivery profiles were collected in vitro in physiological solution at pH 7.4. It has been possible to observe a close correlation between the drug release kinetic and the textural properties of the carriers.
2010
132
258
267
Nanoporous silica; Textural properties; Drug delivery
E. Ghedini; M. Signoretto; F. Pinna; V. Crocellà; L. Bertinetti; G. Cerrato
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2318/74773
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