A fast, solvent-free method is described for the synthesis of substituted quinoline derivatives via Friedlander cyclization, employing a reusable solid catalyst (silica-propylsulfonic acid). Although it worked best under microwave irradiation (with generally more than 90% isolated yields in 30min), the reaction was also feasible under conventional heating (with fair to good yields in about 5h).
Fast, Solvent-Free, Microwave-Promoted Friedlander Annulation with a Reusable Solid Catalyst
GARELLA, Davide;BARGE, Alessandro;CRAVOTTO, Giancarlo
2010-01-01
Abstract
A fast, solvent-free method is described for the synthesis of substituted quinoline derivatives via Friedlander cyclization, employing a reusable solid catalyst (silica-propylsulfonic acid). Although it worked best under microwave irradiation (with generally more than 90% isolated yields in 30min), the reaction was also feasible under conventional heating (with fair to good yields in about 5h).
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