In this work the synthesis and the study of both the NO-donating properties and in vitro vasodilating activities of a series of water soluble furoxans are reported. Results obtained show that appropriate substitution on the furoxan ring allows modulation of NO-donating properties over a wide range as well as spontaneous NO-release in physiological conditions. Correlation between the initial rates of the NO-release and the in vitro vasodilating potencies of the water soluble furoxans analyzed is also discussed.

Furoxan derivatives as NO-donors

DI STILO, Antonella;SORBA, Giovanni;MEDANA, Claudio;FRUTTERO, Roberta;GASCO, Alberto
1997

Abstract

In this work the synthesis and the study of both the NO-donating properties and in vitro vasodilating activities of a series of water soluble furoxans are reported. Results obtained show that appropriate substitution on the furoxan ring allows modulation of NO-donating properties over a wide range as well as spontaneous NO-release in physiological conditions. Correlation between the initial rates of the NO-release and the in vitro vasodilating potencies of the water soluble furoxans analyzed is also discussed.
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NITRIC-OXIDE
DiStilo A; Sorba G; Medana C; Fruttero R; Gasco A
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/77428
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