Stearic acid solid lipid nanoparticles (SLN) were prepared according to the coacervation technique, consisting in fatty acid precipitation of alkaline salt from a solution. SLN can encapsulate Amphotericin B with high efficiency in its monomeric form. SLN markedly increase in vitro drug toxicity towards Saccharomyces cerevisiae (taken as model yeast), expressed as potassium leakage. Yeast susceptibility towards Amphotericin B is increased when the drug is loaded in nanoparticles compared to the free drug, even if inhibition is limited by drug encapsulation within lipid matrix.

Amphotericin B loaded SLN prepared with the coacervation technique

BIANCO, Maria Ausilia;GALLARATE, Marina;TROTTA, Michele;BATTAGLIA, Luigi Sebastiano
2010

Abstract

Stearic acid solid lipid nanoparticles (SLN) were prepared according to the coacervation technique, consisting in fatty acid precipitation of alkaline salt from a solution. SLN can encapsulate Amphotericin B with high efficiency in its monomeric form. SLN markedly increase in vitro drug toxicity towards Saccharomyces cerevisiae (taken as model yeast), expressed as potassium leakage. Yeast susceptibility towards Amphotericin B is increased when the drug is loaded in nanoparticles compared to the free drug, even if inhibition is limited by drug encapsulation within lipid matrix.
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http://www.editionsdesante.fr
SLN - Coacervation – Amphotericin B – Yeasts – Saccharomyces cerevisiae.
M.A. Bianco; M. Gallarate; M. Trotta; L. Battaglia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2318/79786
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